| Time | Event | Score |
|---|
| 6:00 pm | De Smet at SLUH | Rivalry |
| 6:00 pm | McCluer at Hazelwood East | Rivalry |
| 6:00 pm | CBC at Chaminade | Rivalry |
| 6:00 pm | John Burroughs at Lutheran North | Rivalry |
| 6:30 pm | Cardinal Ritter at Francis Howell | Rivalry |
| 7:00 pm | Jerseyville at Charleston, Illinois | Rivalry |
| 7:00 pm | St. Charles at Fort Zumwalt South | Rivalry |
| 7:00 pm | Strafford at Springfield Catholic | Rivalry |
| 7:00 pm | Grandview K.C. at St. Joseph Central | Rivalry |
| 7:00 pm | Mill Valley, Kansas at Lee's Summit North | Rivalry |
| 7:00 pm | South Callaway at Lexington | Rivalry |
| 7:00 pm | Battle at Helias | Rivalry |
| 7:00 pm | Centralia, Mo. at Clark County | Rivalry |
| 7:00 pm | North Kansas City at Excelsior Springs | Rivalry |
| 7:00 pm | Pierce City at Sarcoxie | Rivalry |
| 7:00 pm | Webster Groves at Parkway South | Rivalry |
| 7:00 pm | East Buchanan at Lawson | Rivalry |
| 7:00 pm | Bayless at Crystal City | Rivalry |
| 7:00 pm | Fulton at Westran | Rivalry |
| 7:00 pm | KC Central at Ruskin | Rivalry |
| 7:00 pm | Diamond at TBD | Rivalry |
| 7:00 pm | Liberty (Wentzville) at Warrenton | Rivalry |
| 7:00 pm | Willard at Waynesville | Rivalry |
| 7:00 pm | South Harrison at Marceline | Rivalry |
| 7:00 pm | Marshfield at Carl Junction | Rivalry |
| 7:00 pm | Edwardsville at Jackson | Rivalry |
| 7:00 pm | Gillespie at Greenville | Rivalry |
| 7:00 pm | California at Southern Boone | Rivalry |
| 7:00 pm | KC Northeast at University Academy | Rivalry |
| 7:00 pm | Holt at Orchard Farm | Rivalry |
| 7:00 pm | St. Pius X (Kansas City) at Cameron | Rivalry |
| 7:00 pm | Oakville at Summit | Rivalry |
| 7:00 pm | Collinsville at Carbondale | Rivalry |
| 7:00 pm | Mexico at Odessa | Rivalry |
| 7:00 pm | Rochelle vs Highland at Illinois Wesleyan University | Rivalry |
| 7:00 pm | Stockton at Ash Grove | Rivalry |
| 7:00 pm | Hogan Prep at St. Mary's Academy, Kan. | Rivalry |
| 7:00 pm | Pana at Piasa Southwestern | Rivalry |
| 7:00 pm | Vianney at Francis Howell Central | Rivalry |
| 7:00 pm | West Plains at Springfield Hillcrest | Rivalry |
| 7:00 pm | Warrensburg at Moberly | Rivalry |
| 7:00 pm | Clever at Reeds Spring | Rivalry |
| 7:00 pm | Nashville at Wesclin | Rivalry |
| 7:00 pm | Veritas Christian at Missouri Military Academy | Rivalry |
| 7:00 pm | Chester at Freeburg | Rivalry |
| 7:00 pm | Summit Christian at Clinton | Rivalry |
| 7:00 pm | Lindbergh at Ladue | Rivalry |
| 7:00 pm | Seneca at Nevada | Rivalry |
| 7:00 pm | Knob Noster at St. Pius X | Rivalry |
| 7:00 pm | Carlyle at Caruthersville | Rivalry |
| 7:00 pm | Grain Valley at William Chrisman | Rivalry |
| 7:00 pm | Kearney at Smithville | Rivalry |
| 7:00 pm | Shawnee Mission West at Lincoln College Prep | Rivalry |
| 7:00 pm | Park Hill South at Oak Park | Rivalry |
| 7:00 pm | Sullivan at Union | Rivalry |
| 7:00 pm | Raytown South at Liberty (KC) | Rivalry |
| 7:00 pm | Effingham at Mater Dei | Rivalry |
| 7:00 pm | Logan-Rogersville at Springfield Central | Rivalry |
| 7:00 pm | Savannah at Kirksville | Rivalry |
| 7:00 pm | Brookfield at Highland, Missouri | Rivalry |
| 7:00 pm | Russellville at Cass Midway | Rivalry |
| 7:00 pm | Sikeston at Cape Girardeau Central | Rivalry |
| 7:00 pm | Anna-Jonesboro at Massac County | Rivalry |
| 7:00 pm | Washington (Kan.) at KC Southeast | Rivalry |
| 7:00 pm | Granite City at Cahokia | Rivalry |
| 7:00 pm | Du Quoin at Herrin | Rivalry |
| 7:00 pm | KIPP Kansas City at Pembroke Hill | Rivalry |
| 7:00 pm | Duchesne at Tolton Catholic | Rivalry |
| 7:00 pm | Raymore-Peculiar at Blue Springs | Rivalry |
| 7:00 pm | Civic Memorial at Roxana | Rivalry |
| 7:00 pm | Carthage at Glendale | Rivalry |
| 7:00 pm | Hayti at Scott City | Rivalry |
| 7:00 pm | Crest Ridge at Lincoln | Rivalry |
| 7:00 pm | Lathrop at North Platte | Rivalry |
| 7:00 pm | Chillicothe at Maryville | Rivalry |
| 7:00 pm | Lee's Summit at Blue Springs South | Rivalry |
| 7:00 pm | El Dorado Springs at Pleasant Hope | Rivalry |
| 7:00 pm | Parkway North at Parkway Central | Rivalry |
| 7:00 pm | Hannibal at Troy Buchanan | Rivalry |
| 7:00 pm | Cole Camp at Sherwood | Rivalry |
| 7:00 pm | Riverview Gardens at Mascoutah | Rivalry |
| 7:00 pm | Hickman at Capital City | Rivalry |
| 7:00 pm | Valle Catholic at Potosi | Rivalry |
| 7:00 pm | North Point at Timberland | Rivalry |
| 7:00 pm | Houston at Salem | Rivalry |
| 7:00 pm | Fair Grove at Buffalo | Rivalry |
| 7:00 pm | Pacific at St. Clair | Rivalry |
| 7:00 pm | Mark Twain at Winfield | Rivalry |
| 7:00 pm | Osage at Blair Oaks | Rivalry |
| 7:00 pm | Van Horn at Truman | Rivalry |
| 7:00 pm | Kirkwood at Lafayette | Rivalry |
| 7:00 pm | Republic at Ozark | Rivalry |
| 7:00 pm | Centralia, Kan. at Mid-Buchanan | Rivalry |
| 7:00 pm | St. Mary's at O'Fallon | Rivalry |
| 7:00 pm | Staley at Park Hill | Rivalry |
| 7:00 pm | Butler at Versailles | Rivalry |
| 7:00 pm | KC Center at Harrisonville | Rivalry |
| 7:00 pm | Lee's Summit West at Liberty North | Rivalry |
| 7:00 pm | St. Vincent at Perryville | Rivalry |
| 7:00 pm | Red Bud at Breese Central | Rivalry |
| 7:00 pm | Alton Marquette at Wood River | Rivalry |
| 7:00 pm | Centralia, Illinois at Waterloo | Rivalry |
| 7:00 pm | Chaffee at East Prairie | Rivalry |
| 7:00 pm | Montgomery County at North Callaway | Rivalry |
| 7:00 pm | Raytown at Belton | Rivalry |
| 7:00 pm | Hermann at St. James | Rivalry |
| 7:00 pm | New Madrid County Central at Dexter | Rivalry |
| 7:00 pm | Hollister at Forsyth | Rivalry |
| 7:00 pm | Alton at Triad | Rivalry |
| 7:00 pm | St. Dominic at Borgia | Rivalry |
| 7:00 pm | Neosho at Lebanon | Rivalry |
| 7:00 pm | Adrian at Holden | Rivalry |
| 7:00 pm | Willow Springs at Cabool | Rivalry |
| 7:00 pm | Oak Grove at Pleasant Hill | Rivalry |
| 7:00 pm | Dupo at Madison, Illinois | Rivalry |
| 7:00 pm | Litchfield at Virden North Mac | Rivalry |
| 7:00 pm | Hazelwood Central at Eureka | Rivalry |
| 7:00 pm | St. Joseph Benton at St. Joseph Lafayette | Rivalry |
| 7:00 pm | Seckman at Northwest Cedar Hill | Rivalry |
| 7:00 pm | Francis Howell North at St. Charles West | Rivalry |
| 7:00 pm | Festus at Windsor (Imperial) | Rivalry |
| 7:00 pm | Putnam County, Mo. at Trenton | Rivalry |
| 7:00 pm | Clayton at Gateway STEM | Rivalry |
| 7:00 pm | Macon at Palmyra | Rivalry |
| 7:00 pm | Murphysboro at Benton, Illinois | Rivalry |
| 7:00 pm | Smith-Cotton at Camdenton | Rivalry |
| 7:00 pm | Kennett at Ste. Genevieve | Rivalry |
| 7:00 pm | Belleville East vs Althoff at Belleville Township Stadium | Rivalry |
| 7:00 pm | Olathe North at Rockhurst | Rivalry |
| 7:00 pm | Jefferson at Herculaneum | Rivalry |
| 7:00 pm | Carrollton at Lone Jack | Rivalry |
| 7:00 pm | Soldan at Lutheran St. Charles | Rivalry |
| 7:00 pm | Fort Zumwalt North at Fort Zumwalt West | Rivalry |
| 7:00 pm | Webb City at Kickapoo | Rivalry |
| 7:00 pm | Marquette at Pattonville | Rivalry |
| 7:00 pm | Winnetonka at KC East | Rivalry |
| 7:00 pm | Wright City at Bowling Green | Rivalry |
| 7:00 pm | De Soto at North County | Rivalry |
| 7:00 pm | Lafayette County at Warsaw | Rivalry |
| 7:00 pm | Sparta at Central A&M | Rivalry |
| 7:00 pm | Joplin at Nixa | Rivalry |
| 7:00 pm | Jefferson City at Rock Bridge | Rivalry |
| 7:00 pm | Farmington at Poplar Bluff | Rivalry |
| 7:00 pm | Confluence at Portageville | Rivalry |
| 7:00 pm | Boonville at Hallsville | Rivalry |
| 7:00 pm | Cassville at East Newton | Rivalry |
| 7:00 pm | South Shelby at Monroe City | Rivalry |
| 7:00 pm | West Frankfort at Carterville | Rivalry |
| 7:00 pm | Lighthouse Christian at Parkview | Rivalry |
| 7:00 pm | Eldon at Owensville | Rivalry |
| 7:00 pm | Tipton at Lamar | Rivalry |
| 7:00 pm | Columbia at Taylorville | Rivalry |
| 7:00 pm | Normandy at Belleville West | Rivalry |
| 7:00 pm | Vandalia at Carlinville | Rivalry |
| 7:00 pm | Marshall at Richmond | Rivalry |
| 7:00 pm | Staunton at Hillsboro, Illinois | Rivalry |
| 7:00 pm | Branson at Bolivar | Rivalry |
| 7:00 pm | Platte County at Fort Osage | Rivalry |
| 7:00 pm | West Platte at Penney | Rivalry |
| 7:00 pm | Harrisburg, Illinois at Pinckneyville | Rivalry |
| 7:00 pm | St. Michael the Archangel at Hayden, Kan. | Rivalry |
| 7:00 pm | McDonald County at Mount Vernon | Rivalry |
| 7:00 pm | Marion at Mount Vernon, Illinois | Rivalry |
| 7:00 pm | Mountain Grove at Ava | Rivalry |
| 7:00 pm | Mount Zion at Salem, Illinois | Rivalry |
| 7:00 pm | Aurora at Monett | Rivalry |
| 7:30 pm | Elmhurst IC Catholic at Chicago St. Ignatius | Rivalry |
| 7:30 pm | Washington at Hillsboro | Rivalry |