| 6:00 pm | MICDS-48 at Chaminade-14 - Final | 48-14 |
| 6:00 pm | Jennings-0 at Lutheran North-52 - Final | 52-0 |
| 6:00 pm | SLUH-43 at Ritenour-40 - Final | 43-40 |
| 6:00 pm | Fort Zumwalt East-20 at Parkway North-42 - Final | 42-20 |
| 6:00 pm | Marquette-0 at CBC-48 - Final | 48-0 |
| 6:00 pm | Ladue-16 at Hazelwood East-43 - Final | 43-16 |
| 6:00 pm | Lincoln-Way East-38 at Minooka-7 - Final | 38-7 |
| 6:30 pm | Elmhurst York-35 at Oswego-17 - Final | 35-17 |
| 7:00 pm | Hallsville-26 at St. Charles West-22 - Final | 26-22 |
| 7:00 pm | Macon-19 at South Shelby-48 - Final | 48-19 |
| 7:00 pm | East Newton-28 at Forsyth-31 - Final | 31-28 |
| 7:00 pm | Union-13 at Gateway STEM-14 - Final | 14-13 |
| 7:00 pm | Moberly-49 at Wright City-42 - Final | 49-42 |
| 7:00 pm | Lawson-14 at Brookfield-28 - Final | 28-14 |
| 7:00 pm | South Callaway-6 at Lafayette County-42 - Final | 42-6 |
| 7:00 pm | Ozark-8 at Nixa-35 - Final | 35-8 |
| 7:00 pm | Chicago St. Rita-21 at Villa Park Willowbrook-9 - Final | 21-9 |
| 7:00 pm | Lift for Life-42 at Borgia-2 - Final | 42-2 |
| 7:00 pm | Neosho-14 at Carthage-35 - Final | 35-14 |
| 7:00 pm | Aurora-6 at Seneca-41 - Final | 41-6 |
| 7:00 pm | Malden-8 at Crystal City-36 - Final | 36-8 |
| 7:00 pm | Butler-6 at Pembroke Hill-49 - Final | 49-6 |
| 7:00 pm | St. Pius X-19 at Hermann-26 - Final | 26-19 |
| 7:00 pm | Poplar Bluff-21 at Cape Girardeau Central-28 - Final | 28-21 |
| 7:00 pm | St. James-20 at Strafford-42 - Final | 42-20 |
| 7:00 pm | Downers Grove South-20 at LaGrange Lyons-63 - Final | 63-20 |
| 7:00 pm | Moline-14 at Quincy-44 - Final | 44-14 |
| 7:00 pm | Fort Osage-6 at St. Pius X (Kansas City)-36 - Final | 36-6 |
| 7:00 pm | Logan-Rogersville-27 at West Plains-34 - Final | 34-27 |
| 7:00 pm | St. Joseph Central-0 at Platte County-50 - Final | 50-0 |
| 7:00 pm | Fort Zumwalt West-35 at Fort Zumwalt North-31 - Final | 35-31 |
| 7:00 pm | Osage-7 at Warrenton-42 - Final | 42-7 |
| 7:00 pm | Van Horn-7 at Kearney-49 - Final | 49-7 |
| 7:00 pm | Miller-0 at Marionville-22 - Final | 22-0 |
| 7:00 pm | Summit-7 at Lafayette-49 - In Progress | 49-7 |
| 7:00 pm | East Prairie-6 at Caruthersville-41 - Final | 41-6 |
| 7:00 pm | Cass Midway-14 at Ash Grove-36 - Final | 36-14 |
| 7:00 pm | Houston-0 at Mountain View-Liberty-42 - Final | 42-0 |
| 7:00 pm | Holden-18 vs KIPP Kansas City Legacy-26 at Kansas City Center - Final | 26-18 |
| 7:00 pm | Knob Noster-13 at Boonville-40 - Final | 40-13 |
| 7:00 pm | Sarcoxie-0 at Warsaw-39 - Final | 39-0 |
| 7:00 pm | Raymore-Peculiar-7 at Lee's Summit North-42 - Final | 42-7 |
| 7:00 pm | Pacific-42 at Sullivan-20 - Final | 42-20 |
| 7:00 pm | Pierce City-20 at Windsor (Sedalia)-8 - Final | 20-8 |
| 7:00 pm | Lisle Benet Academy-6 at Rochelle-38 - Final | 38-6 |
| 7:00 pm | Camdenton-17 at Helias-45 - Final | 45-17 |
| 7:00 pm | Crest Ridge-0 at Tipton-69 - Final | 69-0 |
| 7:00 pm | Savannah-11 at Smithville-10 - Final | 11-10 |
| 7:00 pm | Peoria, Illinois-52 at Thornton Fractional North-14 - Final | 52-14 |
| 7:00 pm | Maysville-0 at Hamilton-43 - Final | 43-0 |
| 7:00 pm | Nevada-26 at Warrensburg-28 - Final | 28-26 |
| 7:00 pm | Bolivar-24 at Carl Junction-6 - Final | 24-6 |
| 7:00 pm | Mount Prospect Prospect-49 at Normal Community-52 - Final | 52-49 |
| 7:00 pm | Stockton-8 at Lamar-50 - Final | 50-8 |
| 7:00 pm | North County-10 at Festus-35 - Final | 35-10 |
| 7:00 pm | Mountain Grove-21 at Mount Vernon-35 - Final | 35-21 |
| 7:00 pm | Springfield Hillcrest-27 at Republic-54 - Final | 54-27 |
| 7:00 pm | Francis Howell-14 at Kirkwood-42 - Final | 42-14 |
| 7:00 pm | Fredericktown-20 at Dexter-42 - Final | 42-20 |
| 7:00 pm | East Buchanan-7 at Mid-Buchanan-20 - Final | 20-7 |
| 7:00 pm | Lebanon-47 at Capital City-24 - Final | 47-24 |
| 7:00 pm | Cole Camp-8 at Westran-50 - Final | 50-8 |
| 7:00 pm | Fayette-6 at Harrisburg, Missouri-16 - Final | 16-6 |
| 7:00 pm | Webb City-21 at Grain Valley-9 - Final | 21-9 |
| 7:00 pm | North Kansas City-20 at Oak Park-54 - Final | 54-20 |
| 7:00 pm | Southern Boone-0 at Blair Oaks-66 - Final | 66-0 |
| 7:00 pm | Blue Springs-12 at Blue Springs South-19 - Final | 19-12 |
| 7:00 pm | Chaffee-14 at Charleston-50 - Final | 50-14 |
| 7:00 pm | Centralia, Mo.-20 at Tolton Catholic-37 - Final | 37-20 |
| 7:00 pm | Ste. Genevieve-26 at Park Hills Central-16 - Final | 26-16 |
| 7:00 pm | Cameron-35 at Richmond-20 - Final | 35-20 |
| 7:00 pm | St. Dominic-14 at Rock Bridge-35 - Final | 35-14 |
| 7:00 pm | North Platte-26 at Milan-6 - Final | 26-6 |
| 7:00 pm | Washington-14 at Eureka-13 - Final | 14-13 |
| 7:00 pm | Kelly-14 at Valle Catholic-52 - Final | 52-14 |
| 7:00 pm | Liberty North-10 at Liberty (KC)-13 - Final | 13-10 |
| 7:00 pm | Polo-19 at West Platte-49 - Final | 49-19 |
| 7:00 pm | Clark County-8 at Monroe City-48 - Final | 48-8 |
| 7:00 pm | Kickapoo-7 at Joplin-21 - Final | 21-7 |
| 7:00 pm | Hoffman Estates-21 at Lincoln-Way Central-49 - Final | 49-21 |
| 7:00 pm | Oak Grove-24 at St. Michael the Archangel-23 - Final | 24-23 |
| 7:00 pm | Harrisonville-20 at Pleasant Hill-43 - Final | 43-20 |
| 7:00 pm | Oakville-7 at Seckman-34 - Final | 34-7 |
| 7:00 pm | Thayer-26 at Fair Grove-48 - Final | 48-26 |
| 7:00 pm | Louisiana-0 at St. Vincent-26 - Final | 26-0 |
| 7:00 pm | Chillicothe-0 at Maryville-35 - Final | 35-0 |
| 7:00 pm | Mexico-27 at Hannibal-42 - Final | 42-27 |
| 7:00 pm | Peoria Notre Dame-29 at Mount Zion-43 - Final | 43-29 |
| 7:00 pm | Scotland County-7 at Putnam County, Mo.-14 - Final | 14-7 |
| 7:00 pm | Chicago Whitney Young-0 at Bradley-Bourbonnais-42 - Final | 42-0 |
| 7:00 pm | Lincolnshire Stevenson-35 at Glenbard East-7 - Final | 35-7 |
| 7:00 pm | Westminster-0 at Orchard Farm-39 - Final | 39-0 |
| 7:00 pm | Summit Christian-6 at Odessa-52 - Final | 52-6 |
| 7:00 pm | Jefferson-12 at Bowling Green-60 - Final | 60-12 |
| 7:00 pm | St. Mary's-0 at Cardinal Ritter-38 - Final | 38-0 |
| 7:00 pm | Chicago Agricultural Science-6 at Dixon-51 - Final | 51-6 |
| 7:00 pm | Park Hill South-7 at Park Hill-54 - Final | 54-7 |
| 7:00 pm | Pattonville-30 at De Smet-48 - Final | 48-30 |
| 7:00 pm | Francis Howell Central-25 at Troy Buchanan-70 - Final | 70-25 |
| 7:00 pm | Glendale-29 at Branson-50 - Final | 50-29 |
| 7:00 pm | Washington, Illinois-14 at Oak Lawn Richards-42 - Final | 42-14 |
| 7:00 pm | Lindbergh-14 at Jackson-31 - Final | 31-14 |
| 7:00 pm | Rockhurst-14 at Lee's Summit-17 - Final | 17-14 |
| 7:00 pm | North Point-21 at Liberty (Wentzville)-20 - Final | 21-20 |
| 7:00 pm | Hillsboro-7 at Perryville-21 - Final | 21-7 |
| 7:00 pm | Marceline-13 at Salisbury-24 - Final | 24-13 |
| 7:00 pm | Lincoln-14 at Adrian-55 - Final | 55-14 |
| 7:30 pm | Palentine Fremd-28 at Naperville Central-31 - Final | 31-28 |
| 7:30 pm | Barrington-26 at Gurnee Warren-35 - Final | 35-26 |