| Time | Event | Score |
|---|
| 6:00 pm | Springfield Central at St. Dominic | Rivalry |
| 6:00 pm | Gateway STEM-34 vs Lawson-27 at Boonville - Final | 34-27 |
| 6:00 pm | SLUH-13 at De Smet-42 - Final | 42-13 |
| 6:00 pm | MICDS-21 at Lutheran North-46 - Final | 46-21 |
| 6:00 pm | Ritenour at Lindbergh | Rivalry |
| 6:00 pm | Fort Zumwalt West at Francis Howell | Rivalry |
| 7:00 pm | Carlinville at Virden North Mac | Rivalry |
| 7:00 pm | Festus at North County | Rivalry |
| 7:00 pm | California at Boonville | Rivalry |
| 7:00 pm | Alton Marquette-28 at Mater Dei-57 - Final | 57-28 |
| 7:00 pm | St. Mary's at Rock Bridge | Rivalry |
| 7:00 pm | Hermann-36 at Sullivan-35 - Final | 36-35 |
| 7:00 pm | Hallsville at Osage | Rivalry |
| 7:00 pm | Marion at Centralia, Illinois | Rivalry |
| 7:00 pm | Waynesville at Springfield Hillcrest | Rivalry |
| 7:00 pm | Valle Catholic at Park Hills Central | Rivalry |
| 7:00 pm | Poplar Bluff at Fox | Rivalry |
| 7:00 pm | Ste. Genevieve at Potosi | Rivalry |
| 7:00 pm | Tolton Catholic at Quincy Notre Dame | Rivalry |
| 7:00 pm | Salem, Illinois at Breese Central | Rivalry |
| 7:00 pm | Hazelwood East at Clayton | Rivalry |
| 7:00 pm | Windsor (Imperial) at Hillsboro | Rivalry |
| 7:00 pm | Pleasant Hill, Illinois at White Hall North Greene | Rivalry |
| 7:00 pm | Fort Zumwalt North vs Vashon at Soldan | Rivalry |
| 7:00 pm | Fredericktown at De Soto | Rivalry |
| 7:00 pm | Highland at Civic Memorial | Rivalry |
| 7:00 pm | Fort Zumwalt South at Liberty (Wentzville) | Rivalry |
| 7:00 pm | Southern Boone at Eldon | Rivalry |
| 7:00 pm | Chester at Carlyle | Rivalry |
| 7:00 pm | Oakville at Northwest Cedar Hill | Rivalry |
| 7:00 pm | Warrenton at Union | Rivalry |
| 7:00 pm | Camdenton at Bolivar | Rivalry |
| 7:00 pm | Waterloo-21 at Jerseyville-12 - Final | 21-12 |
| 7:00 pm | Pacific at Owensville | Rivalry |
| 7:00 pm | Fort Zumwalt East at Washington | Rivalry |
| 7:00 pm | St. Vincent at Bayless | Rivalry |
| 7:00 pm | Pattonville at Eureka | Rivalry |
| 7:00 pm | Staunton-20 at Piasa Southwestern-26 - Final | 26-20 |
| 7:00 pm | St. James at St. Clair | Rivalry |
| 7:00 pm | Montgomery County at Wright City | Rivalry |
| 7:00 pm | CBC at Lipscomb, Tenn. | Rivalry |
| 7:00 pm | Carbondale at Granite City | Rivalry |
| 7:00 pm | Francis Howell North at Francis Howell Central | Rivalry |
| 7:00 pm | Pana at Hillsboro, Illinois | Rivalry |
| 7:00 pm | North Callaway at Van-Far | Rivalry |
| 7:00 pm | Parkway West-14 at Parkway North-45 - Final | 45-14 |
| 7:00 pm | Elkville Elverado at Wesclin | Rivalry |
| 7:00 pm | Triad at Mascoutah | Rivalry |
| 7:00 pm | Borgia at Cardinal Ritter | Rivalry |
| 7:00 pm | Cuba at St. Pius X | Rivalry |
| 7:00 pm | Sikeston at Jackson | Rivalry |
| 7:00 pm | Carrollton, Illinois at Hardin Calhoun | Rivalry |
| 7:00 pm | Madison, Illinois at Murphysboro | Rivalry |
| 7:00 pm | Timberland-0 at Troy Buchanan-51 - Final | 51-0 |
| 7:00 pm | Bowling Green at South Callaway | Rivalry |
| 7:00 pm | Hickman at Jefferson City | Rivalry |
| 7:00 pm | St. Charles West at Orchard Farm | Rivalry |
| 7:00 pm | Alton at Edwardsville | Rivalry |
| 7:00 pm | Kirkwood at Marquette | Rivalry |
| 7:00 pm | Seckman-49 at Parkway South-7 - Final | 49-7 |
| 7:00 pm | Battle at Smith-Cotton | Rivalry |
| 7:00 pm | St. Charles at Winfield | Rivalry |
| 7:00 pm | Herculaneum at Grandview | Rivalry |
| 7:00 pm | Rolla at Parkview | Rivalry |
| 7:00 pm | Russellville at Crystal City | Rivalry |
| 7:00 pm | McCluer North at Parkway Central | Rivalry |
| 7:00 pm | North Point at Holt | Rivalry |
| 7:00 pm | Nashville at Benton, Illinois | Rivalry |
| 7:00 pm | Dupo-12 at Red Bud-63 - Final | 63-12 |
| 7:00 pm | Farmington at Cape Girardeau Central | Rivalry |
| 7:00 pm | Mark Twain at Louisiana | Rivalry |
| 7:00 pm | Wood River-0 at Columbia-42 - Final | 42-0 |
| 7:00 pm | Jennings at Duchesne | Rivalry |
| 7:00 pm | Lift For Life-14 at Lutheran St. Charles-26 - Final | 26-14 |
| 7:00 pm | Litchfield at Gillespie | Rivalry |
| 7:00 pm | Vianney at Chaminade | Rivalry |
| 7:00 pm | Capital City at Helias | Rivalry |
| 7:00 pm | Lafayette at Ladue | Rivalry |
| 7:00 pm | Mehlville-6 vs Webster Groves-35 at Kirkwood - Final | 35-6 |
| 7:00 pm | Lebanon at Glendale | Rivalry |
| 7:00 pm | Roxana at Freeburg | Rivalry |
| 7:00 pm | Decatur St. Teresa at Principia | Rivalry |
| 7:00 pm | Seaman, Kan. at Blair Oaks | Rivalry |
| 7:00 pm | Vandalia at Greenville | Rivalry |
| 7:00 pm | Cahokia at Mount Vernon, Illinois | Rivalry |
| 7:00 pm | Kickapoo at West Plains | Rivalry |
| 7:00 pm | Althoff at Collinsville | Rivalry |
| 7:30 pm | Winchester West Central at Greenfield, Illinois | Rivalry |